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Index.dat

CCleaner - good overall cleaner, plus index.dat, Firefox cookies

Spider - clean up index.dat files, the original by Ward van Wanrooij.  Spider also available at PCWorld

Free Internet Window Washer - general Internet cleanup including Index.dat files, plus Firefox support

IE Privacy Keeper - nice cleanup product for Firefox and Internet Explorer. Flexible cleaning options. Cleans index.dat without system restart

SuperWinspy - allows user to view index.dat files as well as location bar history, cookies, Internet Cache, Internet History, Recent Documents History, and more. Does not erase these items but comes in handy as a quick means of checking index.dat content as verification of cleanup.

Window Washer (Free Trial) - polished comprehensive cleaner from Webroot, includes index.dat cleanup, custom cleaning items, Mozilla Firefox support, also cleans file slack space and free disk space with multiple pass options including single pass, DOD (3 passes), NSA (7 passes), and Guttman (35 passes). Aesthetic and well-organized GUI.

Tracks Eraser Pro (Free Trial) - by AceSoft, cleans customary items plus support for many items such as Zone Alarm Logs. Also supports Firefox. Cleans index.dat files.

mil Shield (Free Trial) - quality Internet cleanup utility, cleans and shreds index.dat, Firefox tracks

Cyberscrub Privacy Suite (Free Trial) - thorough Internet cleanup including custom items, wipes free and slack space and scrambles deleted files and folders properties and systems transaction file log, numerous wipe methods ranging from a quick one-pass wipe to the 35 pass Guttman method, ISAAC Random Generating Algorithm is provided as an option for additional security. Selected files anf folders may be sanitized easily from the context menu. A Handy Safe is also included for secure document storage. Polished and smooth function.